Scientific Associate (in vitro/in vivo Immunology)
Inseriert am: 27.08.2018
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Apply to JobJob ID248673BRPosition TitleScientific Associate (in vitro/in vivo Immunology)Job DescriptionPurpose:
The Autoimmunity, Transplantation and Inflammation (ATI) disease area at Novartis Institutes for BioMedical Research (NIBR) is looking for a qualified scientific associate with expertise in rodent disease models and ex vivo/in vitro cell biology to join our Integrated Pharmacology team. Reporting to the Lab Head, you will work in a science-driven environment with both exploratory and operational functions and have the opportunity to contribute to the investigation and understanding of novel pathways in immunology.
Your tasks will include:
• Actively contribute to projects aiming at discovering new ways to modulate the immune system for the treatment of autoimmune diseases
• Perform mechanistic and disease studies in rodents
• Implement new in vitro and in vivo lab techniques according to literature, and explore new approaches
• Culture and characterization of primary rodent cells
• Establish and use molecular and in vitro cellular methods (e.g. assessment of different activation parameters of leukocytes) to investigate the function of primary human and mouse leukocytes
• Combinatorial application of a variety of readouts, like multicolor flow cytometry, western blots, ELISA and the assessment of leukocyte differentiation for the characterization of novel immunomodulating substances and pathways
• Induction of antigen-specific tolerance in rodent models.
Use of cellular and biochemical methods to determine activation of complement pathways in primary cells and organs (blood, urine, tissue) derived from rodents or humans• Use of human and rodent material for drug development and target validation
• Interact in a cross-functional and cross-divisional project team active in drug development
• Present results at project team meetings and engage in scientific discussions with the team membersMinimum requirements• MSc, BSc, Diploma or strong apprenticeship in Immunology, Cellular biology, Biochemistry or another relevant scientific discipline
• Fluency in English (oral and written). German is advantageous
• Experience with different rodent disease models
• Experience with experimental autoimmune encephalitis would be a strong bonus
• Experience in rodent necropsy, tissue sampling
• Solid knowledge of a variety of in vitro cell biology methods (flow cytometry, RT-PCR, western blot, stimulation of immune cells, complement assays)
• Documented experience in isolating and handling primary mouse leukocytes
• Proven practical experience in a relevant research environment; immunology background and knowledge of the complement system and/or antigen-specific tolerance is preferred
• Theoretical knowledge of immunology and immunological methods
• Eager to learn and combine new techniques and concepts
• Demonstrated ability to perform exploratory activities independently and within a highly matrix team environment
• Scientific curiosity, initiative, commitment, flexibility and good organization skills
• Good balance between analytical thinking and a practical/pragmatic approachDivisionNIBRBusiness UnitAUTO/TRANS/INFL - NIBRLocationSwitzerlandSiteBaselCompany/Legal EntityNovartis Pharma AGFunctional AreaResearch & DevelopmentJob TypeFull TimeEmployment TypeRegular
