Job Detail

Behind every presentation of each product sold by Roche is the involvement of Pharma Global Technical Operations (PT). Starting with Phase I of the development process and continuing through to product maturity, PT makes medicines at sites around the world and includes more than 10 000 employees worldwide.

"Global Technical Development" (PTD) is an organization of over two thousand people globally that are integral for the mission of Roche to develop meaningful medicines for patients. Therefore, we actively collaborate and develop creative technical solutions to bridge early-stage, late-stage and commercial product needs. The mandate of the group is, to expertly deliver the pipeline and supply quality products to patients. The group excels in its work through innovation, partnership, dedication, and mutual respect and adds value every single day, continuously improving what it does.

“Small Molecules Technical Development” (PTDC) brings a broad range of experience across drug substance (DS), drug product (DP), analytical sciences and manufacturing S&T, and collaborates closely with key partners in the departments Research and Early Development (pRED / gRED), Pharma Technical Development PTD and Commercial Manufacturing (PTG). PTDC is responsible for late stage technical development of our small molecules (SM) pipeline, manufacture of DS and DP for clinical studies and the transfer to the SM manufacturing network.

This position is part of the Drug Product Small Molecules Development organization, reporting to the Section Head of Formulation and Process Research and Development. As a Senior Scientist in this Section, you will serve as project leader in pharmaceutical development projects, that involve both standard and drug delivery technologies, and encompass the development of clinical and market formulation as well as the optimization/scale-up of the manufacturing process. In addition, you will also be responsible to support build-up of new capabilities within the organization, particularly focused on oral drug delivery.

As a Senior Scientist, your responsibilities will include:

• Development of clinical and market formulations and optimization/scale-up of robust manufacturing processes for oral solid drug products using various manufacturing technologies such as wet and dry granulation, tableting, capsule filling and coating


• Facilitate the technology transfers to commercial manufacturing sites and the successful process validation at the sites


• Planning and execution of technical and clinical batches (GMP) applying QbD-based development principles incl. risk analysis tools and statistical approaches


• Authoring and review of technical reports, patent applications, and relevant Quality modules to support IND/NDA filings


• Working collaboratively and cross-functionally to support the development of pharmaceutical dosage forms for NCEs (e.g. Analytics, Packaging Development, Solid State Sciences, global and local Manufacturing Science and Technology)


• Build-up of in house and external capabilities in novel manufacturing technologies

Would you like to support these exciting tasks? We are looking for you if you fulfill the following requirements:

• Hold an advanced degree in pharmaceutical sciences, food chemistry, material sciences or related fields with a background in drug product development of oral dosage forms




• Several years of experience in small molecule oral drug product development, preferably with experience in the QbD based development and scale-up of formulations and manufacturing processes and GMP manufacturing




• Demonstrate excellent interpersonal and influencing skills, with high level of proficiency in German and English




• Are able to think out-of-the-box, and implement innovative solutions via close collaborations within and across functions




• Demonstrate excellent organizational planning and communication skills

Have we piqued your interest? Apply now.