Job Detail

Senior Scientist Preparative HPLC – Technical Development Small Molecules

Behind every presentation of each product sold by Roche is the involvement of Pharma Global Technical Operations (PT). Starting with Phase I of the development process and continuing through to product maturity, PT makes medicines at sites around the world and includes more
than 10 000 employees worldwide.

Global Technical Developmen (PTD) is an organization of over two thousand people globally that are integral for the mission of Roche to develop meaningful medicines for patients. Therefore, we actively collaborate and develop creative technical solutions to bridge early-stage, late-stage
and commercial product needs. The mandate of the group is, to expertly deliver the pipeline and supply quality products to patients. The group excels in its work through innovation, teamwork, dedication, and mutual respect and contributes every single day, continuously improving what it does.

Technical Development Small Molecules (PTDC) manufactures drugs for clinical trials and develops the manufacturing process for commercial supply as well as regulatory packages allowing for successful market applications.

As Senior Scientist for preparative HPLC you are responsible for the following main tasks:

• Process development of purification processes using preparative HPLC for complex synthetic compounds like oligonucleotides or oligopeptides.


• Purification of reference substance or isolation of small amounts of impurities using preparative HPLC for structure elucidation purposes.
  
  
  
  • Technical Supervision of experimental laboratory work conducted by laboratory technicians and practical activities in the laboratory.
  
  
  • Transfer of processes into large scale production for technical and GMP manufacturing internally or to CMOs.
  
  
  • Supervision of preparative HPLC activities performed at Contract Manufacturing Organizations.
  
  
  • Development of control strategies in close collaboration with technical teams.
  
  
  • Authoring of regulatory documents.
  
  

• Providing support to management for developing and implementing strategies and goals (incl. revising and authoring SOPs governing the organisation of and procedures in the department

You have following qualification:

• Ph.D. in chemistry, pharmacy or equivalent or Master with significant background in the relevant field.


• Minimum three years of experience in preparative HPLC preferably in the pharmaceutical industry and including scale-up to manufacturing


• Experience with complex synthetic compounds like oligopeptides or –nucleotides is a plus.


• Experience with ultrafiltration is a strong plus


• Experience with modelling of chromatographic processes/ultrafiltration


• Excellent team player


• Working style driven by initiative, team focus, responsibility and flexibility


• Excellent organisational skills, self-driven, efficient and reliable attitude


• Excellent command of written and spoken English, German is a plus