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PhD-student position 100% - 100% | befristet

Inseriert am: 22.06.2020

PhD-student position
100%


We offer a PhD Student Position on Citrullination in ischemia/reperfusion injury: identifying new therapeutic targets and biomarkers


This project focuses on the impact of citrullination during ischemia/reperfusion injury using state-of-the-art in vitro systems and large animal models.
Protein citrullination is a widespread post-translational modification catalyzed by a family of enzymes, the peptidyl arginine deiminases (PADs). The conversion of arginine to citrulline causes a loss of charge that can have profound effects on protein structure and function. Recently, others and we have shown that release of PAD, in particular PAD4, in the extracellular environment can have deleterious effects and lead to citrullination of plasma proteins. In fact, dysregulation of citrullination and PAD activity has been linked to numerous diseases including thrombosis, rheumatoid arthritis, multiple sclerosis, various cancers, and likely plays key roles in ischemia reperfusion injury.

Tasks & AimsThe aim of the project is to identify novel citrullinated proteins in plasma and tissues in a large animal model of ischemia/reperfusion injury. Both proteomic and biochemistry approaches will be used. Functional characterization of the identified citrullinated proteins will be then evaluated by the use of a 3D microfluidic system in which endothelial cells isolated from vessels will be seeded.RequirementsWe look for an enthusiastic and ambitious student with a strong interest in applying the tools and methods of proteomics and biochemistry to the understanding of biological processes. You will benefit from being a member of a highly interdisciplinary group, allowing exposure to a wide variety of research techniques, ranging from animal models to proteomics, microscopy, microfluidics and cell-based experiments. Fluency in English is a prerequisite for this position. A MSc degree with competitive grades is required.We offerWe offer an inspiring and dynamic research environment, including state-of-the art research facilities, supervision and an exciting project of considerable fundamental and applied relevance. Specific project tasks can be tailored to the interests and training priorities of the student. The Department for Biomedical Research at the University of Bern is close to the vibrant city center of Bern. PhD students are paid according to standard rates set out by the Swiss National Science Foundation. As a PhD-student you will be enrolled in the Graduate School for Cellular and Biomedical Sciences (GCB) of the University of Bern and follow specific, high-level courses and lectures relevant for your field of research.ApplicationHow to apply: Prepare a single pdf including i) a letter of motivation, ii) a detailed CV, iii) copies of University grades and iv) the names and addresses of two referees and send it directly to Dr. Nicoletta Sorvillo: nicoletta.sorvillo@dbmr.unibe.ch

The position is available from July 2020 and is for 3-4 years. For more information, feel free to contact Dr. Nicoletta Sorvillo directly


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