Barcelona, July 10th, 2020

Computational Biology associate

The Company
STALICLA is a biotech company developing a first in class precision medicine platform to
accelerate drug development for patients with Neurodevelopmental Disorders (NDDs). First
focus of development has been Autism Spectrum Disorder (ASD). Today, patients diagnosed
with ASD account for 1-1.5% of the world population and the condition remains a high unmet
medical need.

In its Geneva and Barcelona units, STALICLA has assembled a world class team of
experienced drug developers and computational biologists. The company is recognized as a
disruptive player, using its Systems Biology & statistical modelling platform to identify
subgroups of patients with ASD and corresponding candidate drugs.
It is the first time that such technologies have been utilized within the field of
neurodevelopment with the potential to change the direction of the specialty.

In just over 3 years, the STALICLA platform has already proven successful in
expediting and de-risking drug development for a first subgroup of patients with
Autism and identifying two additional subgroups.

Background
STALICLA is expanding on its Discovery and Data Science (DDS) unit in Barcelona. The DDS
unit of STALICLA in Spain focuses on the identification of subgroups of patients based on
genetic, phenotypic and clinical factors, integrating molecular, anatomical and medical data
via computational systems biology. Through biomedical big data analysis, the research unit
leverages on existing molecular entities to bring tailored treatments to patients with NDDs.
The fundamental elements of STALICLA research platform include the computational
analysis of omics data (proteomics, genomics, transcriptomics, metabolomics, etc.), clinical
text mining and personalized systems medicine. The main analyses involve bioinformatics,
statistical modeling and machine learning centered on the biology of diseases, comorbidities
and pharmacology.

Position
Title: Computational Biology associate
Location: World Trade Center, Barcelona
Duration: Permanent
Salary: Competitive - depending on experience and profile

Candidates living Barcelona or EU and able to relocate rapidly would be preferable.

The role
The computational biology associate will work closely with the other members of the unit and
contribute to updating STALICLA’s proprietary knowledge bases towards the
characterization of “targetable” molecular, genetic and clinical features in
World Trade Center | Moll de Barcelona, s/n, Edif Este | 08039 Barcelona | Spain | + 34 931 682 868

Barcelona, July 10th, 2020

neurodevelopmental disorders. S/he will participate in processing and analyzing large scale
biomedical data within the context of ongoing computational systems biology projects,
ranging from the identification of biological pathways associated with ASD and comorbid
neurodevelopmental disorders, to the improvement of our next generation sequencing (NGS)
and clinical data mining pipelines. In that context, s/he will be in charge of monitoring
analysis and producing high-quality reports and log files to ensure reproducibility.
Candidates with previous experience on NGS (genomics and/or preferably transcriptomics)
and microarray data analysis, as well as cloud computing, or who are open to learning these
skills, are preferred.

Work environment
The STALICLA DDS office is located by the sea, overlooking the port of Barcelona and it has
easy access to the public transportation. Perks at the office include free coffee, tea and fresh
fruits.

Desired skills & software
Must have

• Linux, shell scripting


• R (+Bioconductor) and/or Python


• Demonstrable experience in the analysis of RNA-seq and/or microarray data


• Experience with cluster and/or cloud computing (AWS preferred)

Good to have

• Experience with other NGS techniques (preferably genomics, i.e. WGS, WES)


• Experience with text mining and NLP (preferably on clinical and biomedical text)


• Git, Makefile, Nextflow (or equivalent), Docker


• MySQL, Neo4j, MongoDB or equivalent


• Prior experience in the field of Neurodevelopmental disorders or CNS genetics

In addition, the candidate is expected to have:

• A high comfort level working in a high paced start-up environment, where a pragmatic,
  resourceful, well organized and effective approach is required with limited resources


• A hands-on, decisive approach and a proven ability to work independently and as a
  team player


• Excellent communication skills in English


• A passionate, energetic and enthusiastic personality that will ensure commitment to
  the company and its vision

World Trade Center | Moll de Barcelona, s/n, Edif Este | 08039 Barcelona | Spain | + 34 931 682 868

Barcelona, July 10th, 2020

Application procedure
If you are ready to take on this step in your career, please send your application to
info@stalicla.com

Due to a high volume of applications, no information will be provided by phone.
Apply only if your profile matches the aforementioned mandatory requirements.
Only applications including a CV and a tailored cover letter in English will be considered.

World Trade Center | Moll de Barcelona, s/n, Edif Este | 08039 Barcelona | Spain | + 34 931 682 868