Detailed structural imaging and comprehensive characterization of the arrhythmogenic myocardial substrate using motion-resolved free-running multidimensional cardiac imaging.
Département DRM - Dpt de radiologie médicale Code emploi Assistant Doctorant - 0131Niveau Hors DECFODate d'entrée souhaitée 02-08-2021Type de contrat CDDDate de fin de contrat 31-07-2025Catégorie professionnelle Médico-techniqueLieu LausanneTaux d'activité 80% - 100% Date de début de publication 24-06-2021 Date de fin de postulation 31-07-2021 Référence 07251-MT-211-2021The Lausanne University Hospital (CHUV) is one of five Swiss university hospitals. Through its collaboration with the Faculty of Biology and Medicine of the University of Lausanne and the EPFL, CHUV plays a leading role in the areas of medical care, medical research and training.
This PhD project will take place in the Department of Radiology at the Lausanne University Hospital (CHUV) and the University of Lausanne (UNIL) in Switzerland under the supervision of Prof. Matthias Stuber and Dr. Jérôme Yerly.
Cardiac arrhythmias are a major cause of death and cardiac morbidity. The vast majority of arrhythmias occur on subtle structural alterations in the cardiac tissue. Over the past decade, multiple MR methods have been introduced to target various tissue components of the diseased myocardium. Unfortunately, the spatial and temporal resolution of such methods is insufficient to depict structural alterations involved in arrhythmogenicity. However, major strides have recently been made in MR methods. The aim of this translational project is therefore the development, implementation, and optimization of a multidimensional cardiac magnetic resonance (CMR) approach to characterize the myocardial arrhythmogenic substrate at high spatial and temporal resolution. This will be accomplished by developing innovative free-running 3D acquisitions augmented with multiple contrast preparations for mapping and advanced augmented multi-dimensional image reconstruction incorporating AI and advanced mathematical tools. This project will leverage on a pre-existing and unique collaboration between the CHUV in Lausanne, Switzerland, a world leading group in translational CMR methods development, and the IHU LIRYC in Bordeaux, a world leading group in cardiac arrhythmia research.
After familiarizing yourself with both the technical (i.e. MR acquisition and reconstruction) and clinical (i.e. cardiac electrophysiology) aspects of the project, you will start by exploiting novel CMR acquisition and reconstruction methods to push the boundaries of spatial and temporal resolution, and to introduce multiple contrasts for the detailed assessment of myocardial structure and tissue composition. Initial development and simulation will be in Matlab, followed by optimization in phantoms and healthy volunteers. In a second step, the CMR methods will be applied in patients and compared to state-of-the-art techniques in collaboration with the IHU LIRYC.
You will be part of a group of ~15 engineers and physicists that is embedded in the hospital. The group has access to 4 state-of-the-art clinical MRI scanners and you will actively collaborate with Siemens Healthcare (on programming the scanners), the IHU LIRYC (on cardiac electrophysiology), as well as the cardiology service of the CHUV.
We are looking for highly motivated candidates with a master’s degree in engineering, physics, life science or a similar degree, preferably at ease with applied mathematics, computer programming, and MRI physics. English proficiency is necessary while French knowledge is an asset
If you become an employee at the Centre Hospitalier Universitaire Vaudois, we will offer you the following :
Contact for information on the function : Dr Jérôme Yerly, Chargé de recherche, au 021 314 13 50
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