Protein Scientist - Principal Scientist I (80-100%)
Inseriert am: 23.06.2021
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Job ID 321824BR Position Title Protein Scientist - Principal Scientist I (80-100%) Apply to Job
Job Description
5 600 people dedicated to discovery in the Novartis Institutes of BioMedical Research collaborate around the globe, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.
Would you like to join our Protein Sciences team as a Principal Scientist conducting cutting-edge research to study multi-protein complexes in the context of disease and drug discovery?
We are seeking a passionate, curious and collaborative protein scientist with demonstrated experience in expression, purification and characterization of multi-protein complexes. In a cross functional team of enthusiastic drug hunters, you will carry out the challenging task of studying disease-relevant protein targets and their interaction networks. You will discover molecules that modulate the function of these targets and thus help produce therapeutic breakthroughs for patients.
You are an empathic listener and persuasive speaker, and you thrive in a matrix environment. In doing so, you will have opportunities to develop and grow your professional network across NIBR and to establish external partnerships or academic collaborations to advance internal programs.
Your responsibilities:
Your responsibilities include, but not limited to:
• Key contributor of projects/workstreams within scientific/technical/early development initiatives. Influences through matrix and project networks. Identifies scientific/technical trends within own discipline that impact projects.
• Executes experiments and interprets complex data to draw logical and innovative conclusions, connecting and enabling work of relevant collaborators within functional community.
• Actively mentors, trains, and supports career development for junior collaborators, especially in own area of deep expertise. Develops and recommends objectives for lab unit, together with broader team.
• Influences a constructive culture within functional community.
• Empowered to carry out novel research and/or technical activities within team, and/or matrix community surrounding field of expertise, which may involve devising new techniques to advance drug discovery, technology or early development projects.
• May lead or co lead projects; influences and achieves results through own scientific.
Minimum requirements
What you’ll bring to the role:
• PhD with background in biochemistry, biophysics or molecular systems biology
• 3-4 years of relevant experience, fluent English
• Expert knowledge of multi-protein complexes: Design of expression vectors (incl. lentiviral-based systems), cell cultivation (mammalian, BV, E. coli), expression of protein complexes in mammalian cells and BV, purification of multi-protein complexes, either endogenous or from recombinant over-expression, for biophysical binding assays and structural biology (crystallography or cryoEM)
• Hands on experience of proximity labeling or affinity purification and MS: Sample preparation for LC-MS/MS experiments, LC-MS/MS measurements and analysis
• Good understanding of research data management workflows (data capture, processing, analysis and reporting)
Desirable requirements:
• Familiarity in visualizing and interpreting structural data to formulate hypotheses on structure-function relationships
• Strong wish to work as an experimental scientist performing at the bench (execute experiments and interpret complex data to draw logical and innovative conclusions)
Why consider Novartis?
769 million lives were touched by Novartis medicines in 2020, and while we are proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what is possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do at Novartis!
Commitment to Diversity & Inclusion:
Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration, and empowers our people to unleash their full potential.
*Some restrictions on flexible working options may apply and will be discussed during interview if applicable.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: talentnetwork.novartis.com/network Division NIBR Business Unit CBT - NIBR Location Switzerland Site Basel Company/Legal Entity Novartis Pharma AG Functional Area Research & Development Job Type Full Time Employment Type Regular Shift Work No
